When complexity science meets implementation science: a theoretical and empirical analysis of systems change

When Science Meets Religion

Understanding complex systems: When Big Data meets network science

Better understanding and controlling complex systems has become a grand challenge not only for computer science, but also for the natural and social sciences. Many of these systems have in common that they can be studied from a network perspective. Consequently methods from network science have proven instrumental in their analysis. In this article, I introduce the macroscopic perspective that ...

Coding Theory Meets Theoretical Computer Science

Theoretical computer scientists have been plying their skills in coding theory since the late 1980s, focusing primarily on the design of faster decoding algorithms. Over the last few years, techniques have begun to flow in the other direction as well, with errorcorrecting codes proving to be useful tools for the solution of problems in theoretical computer science. Ample evidence of the flows i...

Animal clocks: when science meets nature.

Daily rhythms of physiology and behaviour are governed by an endogenous timekeeping mechanism (a circadian 'clock'), with the alternation of environmental light and darkness synchronizing (entraining) these rhythms to the natural day-night cycle. Our knowledge of the circadian system of animals at the molecular, cellular, tissue and organismal levels is remarkable, and we are beginning to under...

BEZ235: When Promising Science Meets Clinical Reality

In the July 2016 issue of The Oncologist, Carlo et al. report the results of a phase I clinical trial [1] of BEZ235 in patients with advancedrenal cell carcinoma(RCC).BEZ235 isadualpan-class PI3K and mTOR inhibitor currently undergoing phase I/II clinical trials as a single agent or in combination in solid tumors and hematologic malignancies. The authors are to be congratulated for reportingthe...